Treatment

Diagnosis

  • Ultrasound scanning checks the size and shape of the thyroid and picks up any nodules (lumps) in the thyroid gland.
  • Thyroid scanning checks the size and shape of the nodules and whether they are overactive, “hot”, or underactive, “cold”.
  • Fine Needle Aspiration Cytology (FNAC): If a nodule is large or has any suspicious features, a fine needle is used to remove cells for investigation.

Treatment

  • Surgery: To remove part or all of the thyroid gland.
  • Radioactive Iodine when appropriate: To ensure that all the thyroid cancer cells are destroyed. After treatment with radioactive iodine, women should avoid conceiving for six months and men should avoid fathering children for six months.
  • Levothyroxine: To replace missing thyroid hormone and suppress the rate of growth of any remaining thyroid cells.

Surgery (Thyroidectomy)

Surgery is normally the first line of treatment for thyroid cancer.  Usually, the whole thyroid gland will need to be removed (total thyroidectomy), although sometimes only one node has to be removed. After a thyroidectomy, it is necessary to take Thyroxine tablets. Regular blood tests are needed to ensure that thyroid hormone levels are correct.

Radioactive Iodine Treatment

Following surgery, Dr. Marie Louise Healy, the Consultant Endocrinologist, meets with the patient to discuss whether radio-iodine (I131) should be used. An appointment is made with Dr. Jennie Cooke and Dr. Geraldine O’Reilly to discuss  special precautions that need to be taken after the treatment. The decision to use radio iodine (I131) treatment after surgery is made based on the size of the cancer and the risk of a recurrence. The Multi-Disciplinary Thyroid Cancer Team uses International Guidelines to help make an individual decision for each patient.  

Radioactive iodine treatment is painless; it involves taking a capsule by mouth.  The iodine131 goes into the bloodstream and kills only thyroid cells.  No other cells in the body are harmed because they cannot take up iodine.  

Thyroid Stimulating Hormone (TSH) encourages thyroid cells to take up the I131.  It is necessary to have a high TSH level to make the treatment successful. There are two ways to achieve this: to stop taking Levothyroxine a few weeks before the therapy or to take TSH as an injection on each of the two days before the I131 is taken.  This second option avoids the need to stop thyroid hormone replacement. 

Treatment Timetable
Treatment is administered in the iodine suite. Because I131 is a form of radiation, special precautions must be taken to prevent other people from being exposed and the patient is cared for in isolation for up to four days. The physicist measures radiation daily to ensure that levels have dropped to a safe level before the patient leaves the hospital.  Advice is given on avoiding close contact with other people on returning home.  

Follow Up and Outlook
Once the treatment has been administered, patients return at three-monthly intervals to Dr. Healy’s Endocrine Outpatient Clinic. As part of the follow up, regular blood tests are necessary. Thyroglobulin (Tg) is a substance only made by thyroid cells. Patients with thyroid cancer who have been treated with surgery and radio iodine should have very little or no Tg in their blood stream. If the cancer comes back, the Tg becomes positive long before the cancer causes symptoms. So the Tg blood test is a marker of thyroid cancer and can pick up recurrence early, allowing for early treatment. One year after treatment, a full work-up (surveillance), with TSH stimulated blood tests and scans, takes place to determine whether the disease has been fully cleared. Patients will have regular checkups for life.