Drug interactions with anticoagulants and/or antiplatelet agents can result in an increased risk of bleeding or thrombosis
Co-administration of methotrexate with trimethoprim can result in myelosuppression and nephrotoxicity
Co-administration of non-steroidal anti-inflammatory drugs with certain drugs including selective serotonin reuptake inhibitors is associated with an increased risk of gastrointestinal bleeding
Drug interactions should always be considered for women using hormonal contraceptives
Certain drug interactions can increase the risk of QT interval prolongation
Tobacco smoking can reduce plasma levels of some drugs
