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NMIC Bulletin Vol. 21 No. 6 Update drug-induced QT interval prolongation

3 January, 2016

Update drug-induced qt interval prolongation

  • QT prolongation is a recognised risk factor for ventricular arrhythmias including torsades de pointes, that may result in sudden cardiac death
  • Many risk factors are associated with QT prolongation; drugs are the most common acquired risk factor
  • Before initiating a QT prolonging drug, patients should be assessed for other risk factors and any modifiable risk factors should be corrected
  • Co-administration of a QT prolonging drug, especially with other QT prolonging drugs and/or hepatic cytochrome P450 isoenzyme inhibitors which interfere with QT prolonging drugs should be avoided