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NMIC bulletin Vol. 26 No. 4 Drug Interactions (2): Frequently Asked Questions

14 December, 2020

Drug Interactions (2): Frequently Asked Questions

  • Drug interactions with anticoagulants and/or antiplatelet agents can result in an increased risk of bleeding or thrombosis
  • Co-administration of methotrexate with trimethoprim can result in myelosuppression and nephrotoxicity
  • Co-administration of non-steroidal anti-inflammatory drugs with certain drugs including selective serotonin reuptake inhibitors is associated with an increased risk of gastrointestinal bleeding
  • Drug interactions should always be considered for women using hormonal contraceptives
  • Certain drug interactions can increase the risk of QT interval prolongation
  • Tobacco smoking can reduce plasma levels of some drugs