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NMIC Bulletin Vol. 27 No. 2 Drug-induced QT prolongation

4 May, 2021

Drug-induced QT prolongation

  • QT prolongation is a recognised risk factor for the development of ventricular arrhythmias including torsades de pointes that may result in sudden cardiac death
  • Many risk factors are associated with QT prolongation; drugs are the most common risk factor
  • Before initiating a QT prolonging drug, patients should be assessed for other risk factors and any modifiable risk factors should be corrected
  • Co-administration of a QT prolonging drug with other QT prolonging drugs and/or hepatic cytochrome P450 isoenzyme inhibitors which interfere with QT prolonging drugs should be avoided