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NMIC Bulletin Vol. 27 No. 1 Direct oral anticoagulants (DOACs)

22 March, 2021

Direct oral anticoagulants (DOACs)

  • Direct oral anticoagulants (DOACs) have different dose criteria depending on the specific indication
  • Dosing errors with DOACs can result in patient harm; under-dosing may increase the risk of embolic events, while over-dosing can result in an increased risk of bleeding
  • The patient’s age, weight, renal function and concomitant medication should be considered when selecting the dose of a DOAC for a specific indication
  • Clinically significant drug-drug interactions can occur with DOACs