Active research programmes:
Prof. O Sullivan directs a translational gastrointestinal (GI) research team in the Trinity Translational Medicine Institute (TTMI) in collaboration with clinical and surgical colleagues. She utilises well established bio-banking structures to drive this GI translational research program. Prof. O Sullivan's current translational research themes include.
1. Development of diagnostic platforms to stratify cancer risk and response to targeted therapies for gastrointestinal diseases.
2. Development of novel patented therapeutics to be used in the neoadjuvant and adjuvant treatment setting for gastrointestinal cancer patients (Colorectal and Oesophageal cancers).
3. Elucidating how the tumour microenvironment cross talks to the immune system in GI patients.
4. Importance of metabolism, inflammation and obesity in driving disease progression and in regulating treatment response in GI diseases.
The outputs of these translational themes will benefit patient care, treatment and management for gastrointestinal diseased patients