Professor Vandenberghe graduated from University College Dublin and completed early training in Ireland before pursuing a PhD in the molecular pathogenesis of mantle cell lymphoma in the Centre for Human Genetics, University of Leuven (KUL).

She then went on to complete haematology training at the University College London Hospitals, with specific training in lymphoma diagnosis and management; including stem cell transplantation.

Professor Vandenberghe is active in clinical research with more than 100 peer reviewed publications which include molecular pathogenesis of lymphoid disorders and the role of stem cell transplantation and other novel therapies in the management of lymphoid disorders.  She is a collaborator in international clinical trials groups including LYSA, EBMT, ERIC, German CLL Group, EORTC and NCRN (UK).

She collaborates with Professor Adrian Bracken (Smurfit School of Genetics, Trinity College Dublin) on the role of EZH2 in B lymphoid disorders.

Professor Vandenberghe is a member of the American Society of Haematology, European Haematology Association and on the Lymphoma Working party of the European Blood and Marrow Transplantation (EBMT) Group.

She was a founding member of the Lymphoma Forum of Ireland (LFI) which is a multidisciplinary, all-Ireland Group of doctors, nurses and scientists who meet for educational and research interests.